IRED - Imine-reducing enzymes

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IRED database completion

Paper search score
60%
'Thorough' search carried out in the last 18 months by William Finnigan
Data entry completion
38%
32 out of 83
Priority papers completed
100%
5 out of 5

IRED curation team

(18) * William Finnigan - University of Manchester

(2) * yuqi yu - University of Manchester

(2) Rachel Heath - University of Manchester

(1) Tom Thorpe - University of Manchester

(1) Tom Lister - UoM

* indicates team admin
( ) shows number of papers curated

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IRED database statistics

731 enzyme records, 528 with protein sequences

12255 UniRef50 homologues

5892 activity records - 55 % active , 44 % inactive

906 unique product molecules

Reactions by IRED

Imine reduction

Featured in 16 IRED papers

Cofactor usage: NADPH --> NADP

Reductive amination

Featured in 13 IRED papers

Multi-step

Cofactor usage: NADPH --> NADP

Ketone amination

Featured in 6 IRED papers

Cofactor usage: NADPH, NH3 --> NADP

Amine oxidation

Featured in 2 IRED papers

Cofactor usage: NADP+ --> NADPH

Iminium reduction

Featured in 2 IRED papers

Cofactor usage: NADPH --> NADP

Amine deracemization

Featured in 1 IRED papers

Multi-step

Cofactor usage: NADPH, Reducing agent --> NADP+

Aldehyde amination

Featured in 0 IRED papers

Cofactor usage: NADPH, NH3 --> NADP

Conjugate reduction eneimine

Featured in 0 IRED papers

Cofactor usage: NADPH --> NADP+, H2O